British National Formulary November 2025 Update

This update contains 32 significant changes, 3 dose changes, 3 new monographs, 1 new preparation, and 1 deleted preparation.

 

Significant Changes:

• Antibacterials, use for prophylaxis: updated guidance for Haemophilus influenzae type b infection: prevention of secondary disease.
• Azithromycin: new indication and dose for prevention of secondary cases of Haemophilus influenzae type b disease.
• Bee venom extract: name change to bee venom extracts.
• Ciprofloxacin: new indication and dose for prevention of secondary cases of Haemophilus influenzae type b disease.
• COVID-19 vaccine: monograph updated to reflect current guidance.
• COVID-19 vaccine: updated guidance for immunisation.
• Diphtheria vaccine: updated guidance for immunisation.
• Factor VIIa (recombinant): name change to factor VIIa.
• Factor XIII A-subunit (recombinant): name change to factor XIII A-subunit.
• Fibrinogen, dried: name change to fibrinogen.
• Grass pollen extract: name change to grass pollen extracts.
• Guselkumab: new indications and doses for Crohn’s disease and ulcerative colitis.
• Haemophilus influenzae type b conjugate vaccine: updated guidance for immunisation.
• Heparin (unfractionated): name change to heparin.
• Hepatitis B vaccine: updated guidance for immunisation.
• House dust mite extract: name change to house-dust mite extracts.
• Hydroxyethylcellulose: name change to hyetellose.
• Immunisation schedule: updated guidance.
• Liraglutide: monograph updated to incorporate new preparations.
• Measles, Mumps and Rubella vaccine: updated guidance for immunisation.
• Meningococcal vaccines: updated guidance for immunisation.
• Paracetamol: reminder that taking paracetamol during pregnancy remains safe [MHRA/CHM advice].
• Paraffin, yellow, soft: name change to yellow soft paraffin.
• Pertussis vaccine: updated guidance for immunisation.
• Pneumococcal vaccine: updated guidance for immunisation.
• Poliomyelitis vaccine: updated guidance for immunisation.
• Protein C concentrate: name change to protein C.
• Silver sulfadiazine: name change to sulfadiazine silver.
• Tetanus vaccine: updated guidance for immunisation.
• Tree pollen extract: name change to tree pollen extracts.
• Vaccination, general principles: updated guidance for vaccines and asplenia, splenic dysfunction, or complement disorders.
• Wasp venom extract: name change to wasp venom extracts.

 

Dose Changes:

• Ergometrine maleate [update to dosing for postpartum haemorrhage caused by uterine atony].
• Ergometrine with oxytocin [update to dosing for postpartum haemorrhage caused by uterine atony].
• Paclitaxel (albumin-bound) [update to indications and dose for non-small cell lung cancer in adults].

 

New Monographs:

• Elahere® [mirvetuximab soravtansine].
• Tzield® [teplizumab].
• Vimkunya® [chikungunya vaccine (inactivated)].

 

New Preparations: Paclitaxel albumin-bound

 

Deleted Preparations: Victoza® [liraglutide].