This update contains 5 significant changes and 4 minor changes.

Significant Changes:

• Achilles tendinopathy — reviewed. A literature search was conducted in November

  2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key

  randomized controlled trials published since the last revision of the topic. The

  Prescribing information section was deleted and a link to the Prodigy topic on

  Analgesia – mild-to-moderate pain has been included in the Management section.

  The information about Achilles tendon rupture has been moved to the Complications

  section to aid navigation. No major changes to clinical recommendations have been

  made.

• Giant cell arteritis — reviewed. A literature search was conducted in November 2025

  to identify evidence-based guidelines, UK policy, systematic reviews, and key

  randomized controlled trials published since the last revision of this topic. No major

  changes to recommendations have been made. An Assessment node has been added

  to the Diagnosis section in line with current Prodigy style. The section on Prescribing

  information has been removed and a link provided to the Prodigy topic on

  Corticosteroids – oral.

• Mastitis and breast abscess — reviewed. A literature search was conducted in

  December 2025 to identify evidence-based guidelines, UK policy, systematic reviews,

  and key randomized controlled trials published since the last revision of this topic. No

  major changes to the recommendations have been made.

• Neuropathic pain – drug treatment — reviewed. A literature search was conducted

  in December 2025 – January 2026 to identify evidence-based guidelines, UK policy,

  systematic reviews, and key randomized controlled trials published since the last

  revision of this topic. Additional information and clarification have been added

  relating to risks of dependence and prescribing off-label. There has been minor

  reorganization of the prescribing section. There have been no major changes to the

  recommendations.

• Squint in children — reviewed. A literature search was conducted in November 2025

  to identify evidence-based guidelines, UK policy, systematic reviews, and key

  randomized controlled trials published since the last revision of the topic. There were

  no significant changes to the topic recommendations. Minor structural changes have

  been made to the topic to align the recommendations with the most recent

  literature.

Minor Changes:

• Acne vulgaris — minor update. The recommendation of two independent

  prescribers of isotretinoin therapy for under 18s has been updated to a single

  prescriber in line with an SPC update.

• Compression stockings — minor update to align information regarding ABPI with

  contemporary guidance.

• Gallstones — minor update in the wording of risk factors for gallstones.

• Sepsis — minor update. Revised the sepsis six in line with the Sepsis Trust manual

  7th edition.