Agilio: Diagnosis and Treatment Guidance December 2025 Update

This update contains 4 significant changes and 8 minor changes.

Significant Changes:

• Analgesia – mild-to-moderate pain — reviewed. A literature search was
  conducted in July 2025 to identify evidence-based guidelines, UK policy,
  systematic reviews, and key randomized controlled trials published since
  the last version of this topic. Changes have been made to
  recommendations in line with the guideline from the National Institute for
  Health and Care Excellence (NICE) on chronic pain, and in line with
  publication of additional warnings from the Medicines and Healthcare
  products Regulatory Agency (MHRA) on the risk of dependence and
  addiction from prolonged use of opioids for non-cancer pain.
• Contraception – emergency — reviewed. A literature search was
  conducted in August 2025 to identify evidence-based guidelines, UK
  policy, systematic reviews, and key randomized controlled trials published
  since the last revision of the topic. Minor changes have been made to align
  with updated guidance from the College of Sexual and Reproductive
  Healthcare (CoSRH) (formerly known as the Faculty of Sexual and
  Reproductive Healthcare). Text has been updated to reflect a revised
  recommendation from CoSRH which states that no interruption of
  breastfeeding is necessary following a single dose of ulipristal acetate
  when given for emergency contraception CoSRH, 2025.
• Hyponatraemia — reviewed. A literature search was conducted in
  September 2025 to identify evidence-based guidelines, UK policy,
  systematic reviews and key randomized controlled trials published since
  the last version of this topic. No major changes to clinical
  recommendations have been made.
• Macular degeneration – age-related — reviewed. A literature search
  was conducted in September 2025 to identify evidence-based guidelines,
  UK policy, systematic reviews, and key randomized controlled trials
  published since the last revision of this topic. No major changes to the
  recommendations have been made.

Minor Changes:

• Autism in adults — minor update. Added additional information
  regarding possible undiagnosed autism in older adults.
• Benign paroxysmal positional vertigo — minor update. A minor
  typographical error has been corrected.
• Constipation — minor update. Information that naldemedine is an option
  for people with short-duration opioid-induced constipation has been added
  in line with the nice technology appraisal naldemedine for treating opioid-
  induced constipation.
• Influenza – seasonal — minor update. Updated to align with the updated
  nice guideline ng253 suspected sepsis in people aged 16 or over.