BNFC December 2025 Update

This update contains 9 significant changes, and 5 deleted monographs.

Significant Changes:

• Amoxicillin: updated indications and dose for prophylaxis of recurrent urinary-tract infection.
• Cefalexin: updated indications and dose for prophylaxis of recurrent urinary-tract infection.
• Isotretinoin: updates to prescribing guidance and survey of services [MHRA/CHM advice].
• Nitrofurantoin: updated indications and dose for prophylaxis of recurrent urinary-tract infection.
• Rasburicase: harm from delayed administration of rasburicase for tumour lysis syndrome [National Patient Safety Alert advice].
• Rasburicase: update to indication and dosing.
• Sodium clodronate: name change to clodronate disodium.
• Trimethoprim: updated indications and dose for prophylaxis of recurrent urinary-tract infection.
• Ulipristal acetate: updated breast-feeding advice.

Deleted Monographs: Castor oil with collodion and colophony; Colestipol hydrochloride; Macrogol 3350 with anhydrous sodium sulfate, potassium chloride, sodium bicarbonate and sodium chloride; Potassium bicarbonate with potassium acid tartrate; Ranitidine.