Martindale December 2025 update

This update contains 6 new monographs and 13 existing monographs have been updated.
Preparations have also been updated for 6 countries.

New Monographs

• Benzoin resin obtained from species of the genus Styrax is the source of Siam benzoin and Sumatra benzoin.
• Ferric subsulfate solution, also known as Monsel’s solution, has been used as a haemostatic.
• Linzagolix is a gonadorelin antagonist used in the management of uterine fibroids and endometriosis.
• Sodium sulfide is used topically for the temporary relief of pain and discomfort caused by ingrown toenails.
• Talquetamab is a bispecific humanised monoclonal antibody that binds to both GPRC5D on multiple myeloma cells and the CD3 receptor on T-cells. It is used in the
  treatment of relapsed or refractory multiple myeloma.
• Zolbetuximab is a chimeric monoclonal antibody used in the treatment of HER-2 negative, CLDN-18.2 positive gastric or gastro-oesophageal junction adenocarcinoma.

Selective Updates – some new, re-validated or changed information

Monographs

• Aluminium Chloride Hexahydrate (formerly Aluminium Chloride).
• Betahistine Dihydrochloride (formerly Betahistine Hydrochloride).
• Bismuth Subsalicylate (formerly Bismuth Salicylate).
• Botulinum Toxin.C1-Esterase Inhibitor (formerly Complement C1 Esterase Inhibitor).
• Doconexent (formerly Docosahexaenoic Acid).
• Doconexent Ethyl (formerly Docosahexaenoic Acid Ethyl Ester).
• Icosapent (formerly Eicosapentaenoic Acid).
• Icosapent Ethyl (formerly Eicosapentaenoic Acid Ethyl Ester).
• Liraglutide.
• Ondansetron.
• Sapropterin Dihydrochloride (formerly Sapropterin Hydrochloride).
• Setmelanotide.

Proprietary Preparations and Manufacturers updated for the following
countries and regions:

• Brazil
• Norway
• Singapore
• Spain
• UK†
• USA†

† Countries updated on an ongoing basis